Molecular Studies on Thyrotropin (TSH) Receptor and Anti-TSH Receptor Antibodies.
نویسندگان
چکیده
منابع مشابه
Folding-dependent binding of thyrotropin (TSH) and TSH receptor autoantibodies to the murine TSH receptor ectodomain.
The mouse TSH receptor ectodomain (mTSHR-ecd) was amplified from murine thyroid complementary DNA and ligated into the pAcGP67B insect cell vector, and the nucleotide sequence was confirmed. Employing a baculovirus-insect cell system, the mTSHR-ecd (amino acids 22-415) was expressed as a fusion protein with the gp67 insect cell signal sequence at the NH2-terminus and a C-terminal six-histidine ...
متن کاملBioassays for TSH Receptor Antibodies: Quo Vadis?
tations of GD [12] . TSHR bioassays show outstanding features. The biological activity of specific immunoglobulins is directly assessed on a fully functional TSHR holoreceptor expressed on intact live cells, a platform that is easily adaptable and tailored to detect Ab of specific function. The TSHR protein structure can be bioengineered and stably expressed in cell lines with protocols optimiz...
متن کاملBioassays for TSH Receptor Antibodies: Quo Vadis?
tations of GD [12] . TSHR bioassays show outstanding features. The biological activity of specific immunoglobulins is directly assessed on a fully functional TSHR holoreceptor expressed on intact live cells, a platform that is easily adaptable and tailored to detect Ab of specific function. The TSHR protein structure can be bioengineered and stably expressed in cell lines with protocols optimiz...
متن کاملBioassays for TSH Receptor Antibodies: Quo Vadis?
tations of GD [12] . TSHR bioassays show outstanding features. The biological activity of specific immunoglobulins is directly assessed on a fully functional TSHR holoreceptor expressed on intact live cells, a platform that is easily adaptable and tailored to detect Ab of specific function. The TSHR protein structure can be bioengineered and stably expressed in cell lines with protocols optimiz...
متن کاملBioassays for TSH Receptor Antibodies: Quo Vadis?
tations of GD [12] . TSHR bioassays show outstanding features. The biological activity of specific immunoglobulins is directly assessed on a fully functional TSHR holoreceptor expressed on intact live cells, a platform that is easily adaptable and tailored to detect Ab of specific function. The TSHR protein structure can be bioengineered and stably expressed in cell lines with protocols optimiz...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1995
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.42.617